Amongst the chemokine signalling axes involved in cancer. chemokine CXCL12 acting on chemokine receptor CXCR4 is particularly significant since it orchestrates migration of cancer cells in a tissue-specific metastatic process. High CXCR4 tumour expression is associated with poor prognosis of lung. brain. https://www.freaknleather.com/product-category/flowmeter/