Numb was originally discovered as an intrinsic cell fate determinant in Drosophila by antagonizing Notch signaling. The present study is to characterize the role of Numb in oxidative stress-induced apoptosis of renal proximal tubular cells. Exposure of NRK52E cells to puromycin aminonucleoside (PA) resulted in caspase 3-dependent apoptosis. https://www.roneverhart.com/Rag-Bone-Dress-Marylebone-Black-Leather-Silk-Chiffon-Size-2-Tiered-Mini-NEW/